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論文一覧
公開件数:85件
No. 著者・共著者名 発表論文の標題 掲載誌名 巻号頁 出版日 ISSN DOI
1 Ishikawa K, Karaki F, Tayama K, Higashi E, Hirayama S, Itoh K, Fujii H
C-Homomorphinan Derivatives as Lead Compounds to Obtain Safer and More Clinically Useful Analgesics
Chem. Pharm. Bull.
65/ 10, 920-929
2017/10

10.1248/cpb.c17-00385
2 Yamamoto N, Okada T, Harada Y, Kutsumura N, Imaide S, Saitoh T, Fujii H, Nagase H
The application of a specific morphinan template to the synthesis of galanthamine
Tetrahedron
73/ 39, 5751-5758
2017/09

10.1016/j.tet.2017.08.014
3 Fujii H, Shimada N, Ohtawa M, Karaki F, Koshizuka M, Hayashida K, Kamimura M, Makino K, Nagamitsu T, Nagase H
Deprotection of silyl ethers by using SO3H silica gel: Application to sugar, nucleoside, and alkaloid derivatives
Tetrahedron
73/ 36, 5425-5429
2017/09

10.1016/j.tet.2017.07.047
4 Watanabea Y, Hayashida K, Saito D, Takahashi T, Sakai J, Nakata E, Kanda T, Iwai T, Hirayama S, Fujii H, Yamakawa T, Nagase H
Design and Synthesis of Novel delta Opioid Receptor Agonists with an Azatricyclodecane Skeleton for Improving Blood-Brain Barrier Penetration
Bioorg. Med. Chem. Lett.
27/ 15, 3495-3498
2017/08

10.1016/j.bmcl.2017.05.072
5 Karaki F, Ohgane K, Imai H, Itoh K, Fujii H
Reactivity of 7-Azanorbornenes in Bioorthogonal Inverse Electron-Demand Diels–Alder Reactions
Eur. J. Org. Chem.
26, 3815-3829
2017/07

10.1002/ejoc.201700411
6 Hayashida K, Hirayama S, Iwai T, Watanabe Y, Takahashi T, Sakai J, Nakata E, Yamakawa T, Fujii H, Nagase H
Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities
Bioorg. Med. Chem. Lett.
27/ 12, 2742−2745
2017/06

10.1016/j.bmcl.2017.04.059
7 藤井秀明,平山重人
オピオイド受容体スプライスバリアント
ペインクリニック
38, S195-S200
2017/04


8 Gotoh L, Saitoh A, Yamada M, Fujii H, Nagase H, Yamada M
Effects of repeated treatment with a delta opioid receptor agonist KNT-127 on hyperemotionality in olfactory-bulbectomized rats
Behav. Brain Res.
323, 11-14
2017/04

10.1016/j.bbr.2016.11.008
9 Asakura M, Fukami T, Nakajima M, Fujii H, Atsuda K, Itoh T, Fujiwara R
Hepatic dipeptidyl peptidase-4 controls pharmacokinetics of vildagliptin in vivo
Drug Metab. Dispos.
45/ 2, 237
2017/02
0090-9556
10.1124/dmd.116.073866
10 Asakura M, Karaki F, Fujii H, Atsuda K, Itoh T, Fujiwara R
Vildagliptin and its metabolite M20.7 induce the expression of S100A8 and S100A9 in human hepatoma HepG2 and leukemia HL-60 cells
Sci. Rep.
6, 35633
2016/10
2045-2322
10.1038/srep35633
11 Yamashita Y, Asakura M, Mitsugi R, Fujii H, Nagai K, Atsuda K, Itoh T, Fujiwara R
MicroRNA expression in the vildagliptin-treated two- and three-dimensional HepG2 cells
Drug Metab. Pharmacokinet.
31/ 3, 201−209
2016/06
1347-4367
10.1016/j.dmpk.2016.02.004
12 Ishikawa K, Mochizuki Y, Hirayama S, Nemoto T, Nagai K, Itoh K, Fujii H
Synthesis and Evaluation of Novel Opioid Ligands with a C-Homomorphinan Skelet
Bioorg Med Chem
24/ 10, 2199−2205
2016/05
0968-0896
10.1016/j.bmc.2016.03.040
13 Kutsumura, N.; Nakajima, R.; Koyama, Y.; Miyata, Y.; Saitoh, T.; Yamamoto, N.; Iwata, S; Fujii, H.; Nagase, H.
Investigation of 7-benzylidenenaltrexone derivatives as a novel structural antitrichomonal lead compound
Bioorg. Med. Chem. Lett.
25/ 21, 4890–4892
2015/11

10.1016/j.bmcl.2015.06.002
14 Nakajima, R.; Yamamoto, N.; Hirayama, S.; Iwai, T.; Saitoh, A.; Nagumo, Y.; Fujii, H.; Nagase, H.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 5, novel pentacyclic propellane derivatives with a 6-amide side chain
Bioorg. Med. Chem.
23/ 19, 6271−6279
2015/10

10.1016/j.bmc.2015.08.036
15 Itoh, K.; Kato, R.; Kinugawa, D.; Kamiya, H.; Kudo, R.; Hasegawa, M.; Fujii, H.; Suga, H.
Photochemically-Induced C-C Bond Formation between Tertiary Amines and Nitrones
Org. Biomol. Chem.
13/ 33, 8919−8924
2015/09

10.1039/C5OB01277E
16 Nagahara, T.; Saitoh, T.; Kutsumura, N.; Irukayama-Tomobe, Y.; Ogawa, Y.; Kuroda, D.; Gouda, H.; Kumagai, H.; Fujii, H.; Yanagisawa, M.; Nagase, H.
Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists
J. Med. Chem.
58/ 20, 7931–7937
2015/08

10.1021/acs.jmedchem.5b00988
17 Nemoto T, Iihara Y, Hirayama S, Iwai T, Higashi E, Fujii H, Nagase H
Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen as δ opioid receptor inverse agonists
Bioorg. Med. Chem. Lett.
25/ 15, 2927–2930
2015/08

10.1016/j.bmcl.2015.05.038
18 Asakura M, Fujii H, Atsuda K, Itoh T, Fujiwara R
Dipeptidyl Peptidase-4 Greatly Contributes to the Hydrolysis of Vildagliptin in Human Liver
Drug Metab. Dispos.
43/ 4, 477−484
2015/04

10.1124/dmd.114.062331
19 Konoura K, Fujii H, Imaide S, Gouda H, Hirayama S, Hirono S, Nagase H
Transformation of naltrexone into mesembrane and investigation of the binding properties of its intermediate derivatives to opioid receptors
Bioorg. Med. Chem.
23/ 3, 439−448
2015/02

10.1016/j.bmc.2014.12.032
20 Asakura M, Nakano M, Hayashida K, Fujii H, Nakajima M, Atsuda K, Itoh T, Fujiwara R
Human nitrilase-like protein does not catalyze the hydrolysis of vildagliptin
Drug Metab. Pharmacokinet.
29/ 6, 463−469
2014/12

10.2133/dmpk.DMPK-14-RG-027
21 Watanabe Y, Kitazawa S, Fujii H, Nemoto T, Hirayama S, Iwai T, Gouda H, Hirono S, Nagase H
Design, Synthesis, and Structure-Activity Relationship of Novel Opioid κ Receptor Selective Agonists: α-Iminoamide Derivatives with an Azabicyclo[2.2.2]octene Skeleton
Bioorg. Med. Chem. Lett.
24/ 21, 4980−4983
2014/11

10.1016/j.bmcl.2014.09.029
22 Hirayama S, Wada N, Kuroda N, Iwai T, Yamaotsu N, Hirono S, Fujii H, Nagase H
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies
Bioorg. Med. Chem. Lett.
24/ 20, 4895−4898
2014/10

10.1016/j.bmcl.2014.08.012
23 Hirayama S, Wada N, Nemoto T, Iwai T, Fujii H, Nagase H
Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton
ACS Med. Chem. Lett.
5/ 8, 868−872
2014/08

10.1021/ml5000542
24 Nagase H, Nakajima R, Yamamoto N, Hirayama S, Iwai T, Nemoto T, Gouda H, Hirono S, Fujii H
Design and Synthesis of Propellane Derivatives with Selective Delta Opioid Receptor Agonism and Their Pharmacologies: Propellane Derivatives with a Quinoline Ring
Bioorg. Med. Chem. Lett.
24/ 13, 2851–2854
2014/07

10.1016/j.bmcl.2014.04.098
25 Fujii H, Hayashida K, Saitoh A, Yokoyama A, Hirayama S, Iwai T, Nakata E, Nemoto T, Sudo Y, Uezono Y, Yamada M, Nagase H
Novel Delta Opioid Receptor Agonists with Oxazatricyclodecane Structure
ACS Med. Chem. Lett.
5/ 4, 368–372
2014/04

10.1021/ml400491k
26 Nagase H, Fujii H
Essential Structure of the κ Opioid Receptor Agonist Nalfurafine for Binding to the κ Receptor
Curr. Pharmacuet. Des.
19/ 42, 7400-7414
2013/12

10.2174/138161281942140105162601
27 Ishikawa K, Tomatsu M, Nagase H, Fujii H
ZINC-ACETIC ACID PROMOTED REDUCTIVE CARBON-NITROGEN BOND CLEAVAGE REACTION OF α-AMINOKETONES
Heterocycles
88/ 2, 1051-1063
2013/12

10.3987/COM-13-S(S)64
28 Nemoto T, Ida Y, Iihara Y, Nakajima R, Hirayama S, Iwai T, Fujii H, Nagase H
The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, δ opioid receptor agonists
Bioorg. Med. Chem.
21/ 24, 7628-7647
2013/12

10.1016/j.bmc.2013.10.032
29 Fujii H, Takahashi T, Nagase H
Non-peptidic δ Opioid Receptor Agonists and Antagonists (2000–2012)
Expert Opin. Ther. Patents
23/ 9, 1181-1208
2013/09

10.1517/13543776.2013.804066
30 Watanabe Y, Kitazawa S, Nemoto T, Hirayama S, Iwai T, Fujii H, Nagase H
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies
Bioorg. Med. Chem.
21/ 11, 3032-3050
2013/06

10.1016/j.bmc.2013.03.026
31 Nemoto, T.; Hirayama, S.; Iwai, T.; Yamamoto, N.; Harada, Y.; Wada, N.; Tomatsu, M.; Ishihara, M.; Fujii, H.; Nagase, H.
The effect of 17-N substituents on the activity of the opioid κ receptor in nalfurafine derivatives
Bioorg. Med. Chem. Lett.
23/ 1, 268–272
2013/01

10.1016/j.bmcl.2012.10.100
32 Wada, N.; Fujii, H.; Koyano, K.; Hirayama, S.; Iwai, T; Nemoto, T.; Nagase, H.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: Synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet)
Bioorg. Med. Chem. Lett.
22/ 24, 7551–7554
2012/12

10.1016/j.bmcl.2012.10.023
33 Fujii, H.; Nakajima, R.; Akiyama, J.; Yamamoto, N.; Hirayama, S; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: Part 3, novel propellane derivatives with pentacyclic skeletons
Bioorg. Med. Chem. Lett.
22/ 24, 7697–7701
2012/12

10.1016/j.bmcl.2012.09.102
34 Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Nagase, H.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 3: Synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies
Bioorg. Med. Chem. Lett.
22/ 24, 7711–7714
2012/12

10.1016/j.bmcl.2012.09.101
35 Nitta A, Fujii H, Sakami S, Satoh M, Nakaki J, Satoh S, Kumagai H, Kawai H
Novel Series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)Butanamides as Potent and Selective Dipeptidyl Peptidase IV Inhibitors
Bioorg Med Chem Lett
22/ 23, 7036–7040
2012/12

10.1016/j.bmcl.2012.09.099
36 Ida, Y.; Matsubara, A.; Nemoto, T.; Saito, M.; Hirayama, S.; Fujii, H.; Nagase, H.
Synthesis of quinolinomorphinan derivatives, as highly selective δ opioid receptor ligands
Bioorg. Med. Chem.
20/ 19, 5810–5831
2012/10

10.1016/j.bmc.2012.08.004
37 Fujii, H.; Yamada, T.; Kohei Hayashida, Kuwada, M.; Hamasaki, A.; Nobuhara, K.; Ozeki, S.; Nagase, H.
APPLICATION OF SO3H SILICA GEL TO DEPROTECTION OF SILYL ETHERS
Heterocycles
85/ 11, 2685–2691
2012/09

10.3987/COM-12-12577
38 Miyata, Y.; Fujii, H.; Uenohara, Y.; Kobayashi, S.; Takeuchi, T.; Nagase, H.
Investigation of 7-benzylidenenaltrexone derivatives as resistance reverser for chloroquine-resistant Plasmodium chabaudi
Bioorg. Med. Chem. Lett.
22/ 16, 5174–5176
2012/08

10.1016/j.bmcl.2012.06.085
39 Nagase, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Fujii, H.
Essential structure of opioid κ receptor agonist nalfurafine for binding to the κ receptor 2: Synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies
Bioorg. Med. Chem. Lett.
22/ 15, 5071–5074
2012/08

10.1016/j.bmcl.2012.05.122
40 Nagase, H.; Imaide, S.; Yamada, T.; Hirayama, S.; Nemoto, T.; Yamaotsu, N.; Hirono, S.; Fujii, H.
Essential structure of opioid κ receptor agonist nalfurafine for binding to κ receptor 1: Synthesis of decahydroisoquinoline derivatives and their pharmacologies
Chem. Pharm. Bull.
60/ 8, 945–948
2012/08

10.1248/cpb.c12-00336
41 Nagase, H Fujii, H
Design and Synthesis of Novel Opioid Ligands and Their Pharmacologies
Heterocycles
85/ 8, 1821–1867
2012/08

10.3987/REV-12-738
42 Watanabe, Y.; Kitazawa, S.; Fujii, H.; Nemoto, T.; Hirayama, S.; Nagase, H.
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies
Bioorg. Med. Chem. Lett.
22/ 8, 2689–2692
2012/04

10.1016/j.bmcl.2012.03.001
43 Nagase, H.; Akiyama, J.; Nakajima, R.; Hirayama, S.; Nemoto, T.; Gouda, H.; Hirono, S.; Fujii, H.
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: Part 2, propellane derivatives with an amide side chain
Bioorg. Med. Chem. Lett.
22/ 8, 2775–2779
2012/04

10.1016/j.bmcl.2012.02.082
44 Ida, Y.; Nemoto, T.; Hirayama, S.; Fujii, H.; Osa, Y.; Imai, M.; Nakamura, T.; Kanemasa, T.; Kato, A.; Nagase, H.
Synthesis of quinolinomorphinan-4-ol derivatives as δ opioid receptor agonists
Bioorg. Med. Chem.
20/ 2, 949–961
2012/01

10.1016/j.bmc.2011.11.047
45 Nagase, H.; Koyano, K.; Wada, N.; Hirayama, S.; Watanabe, A.; Nemoto, T.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 2: synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet)
Bioorg. Med. Chem. Lett.
21/ 20, 6198–6202
2011/10

10.1016/j.bmcl.2011.07.065
46 Saitoh, A.; Sugiyama, A.; Nemoto, T.; Fujii, H.; Wada, K.; Oka, J.; Nagase, H.; Yamada, M.
The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions
Behav. Brain Res.
223/ 2, 271–279
2011/10

10.1016/j.bbr.2011.04.041
47 Hayashida K, Fujii H, Hirayama S, Nemoto T, Nagase H
Rearrangement of 4,5α-epoxymorphinan Derivatives with Carbamoylepoxy Rings Provide Novel Oxazatricyclodecane Structures
Tetrahedron
67/ 35, 6682–6688
2011/09

10.1016/j.tet.2011.04.097
48 Miyata Y, Fujii H, Osa Y, Kobayashi S, Takeuchi T, Nagase H
Opioid δ1 Receptor Antagonist 7-benzylidenenaltrexone as an Effective Resistance Reverser for Chloroquine-resistant Plasmodium chabaudi
Bioorg Med Chem Lett
21/ 16, 4710–4712
2011/08

10.1016/j.bmcl.2011.06.085
49 Nagase, H.; Watanabe, A.; Nemoto, T.; Nakajima, M.; Hasebe, K.; Mochizuki, H.; Fujii, H.
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: synthesis of triplet drugs with morphinan skeletons
Bioorg. Med. Chem. Lett.
21/ 13, 4023–4026.
2011/07

10.1016/j.bmcl.2011.04.134
50 Yamamoto N, Fujii H, Nemoto T, Nakajima R, Momen S, Izumimoto N, Hasebe K, Mochizuki H, Nagase H
Synthesis of New Opioid Derivatives with a Propellane Skeleton and Their Pharmacology: Part 1
Bioorg Med Chem Lett
21/ 13, 4104–4107
2011/07


51 Yamamoto, N.; Fujii, H.; Imaide, S.; Hirayama, S.; Nemoto, T.; Inokoshi, J.; Tomoda, H.; Nagase, H.
Synthesis of (-)-Homogalanthamine from Naltrexone
J. Org. Chem.
76/ 7, 2257–2260
2011/04


52 Nemoto, T.; Yamamoto, N.; Watanabe, A.; Fujii, H.; Hasebe, K.; Nakajima, M.; Mochizuki, H.; Nagase, H.
Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies
Bioorg. Med. Chem.
19/ 3, 1205–1221
2011/02


53 Nagase, H.; Nemoto, T.; Matsubara, A.; Saito, M.; Yamamoto, N.; Osa, Y.; Hirayama, S.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H.
Design and synthesis of KNT-127, a δ-opioid receptor agonist effective by systemic administration.
Bioorg. Med. Chem. Lett.
20/ 21, 6302-6305
2010/11


54 Fujii H, Ida Y, Hanamura S, Osa Y, Nemoto T, Nakajima M,Hasebe K, Nakao K, Mochizuki H, Nagase H
Synthesis of Pyrrolomorphinan Derivatives as κ Opioid Agonists
Bioorg Med Chem Lett
20/ 17, 5035-5038
2010/09


55 Nagase, H.; Imaide, S.; Tomatsu, M.; Hirayama, S.; Nemoto, T.; Sato, N.; Nakajima, M.; Nakao K.; Mochizuki, H.; Gouda, H.; Hirono, S.; Fujii, H.
Investigation of Beckett-Casy model 3: Synthesis of novel naltrexone derivatives with contracted and expanded D–rings and their pharmacology
Bioorg. Med. Chem. Lett.
20/ 12, 3801–3804
2010/06


56 Nagase, H.; Imaide, S.; Tomatsu, M.; Nemoto, T.; Nakajima, M.; Nakao, K.; Mochizuki, H.; Fujii, H.
Investigation of Beckett-Casy model 2: Synthesis of novel 15–16 nornaltrexone derivatives and their pharmacology
Bioorg. Med. Chem. Lett.
20/ 12, 3726–3729
2010/06


57 Yamaotsu N, Fujii H, Nagase H, Hirono S
Identification of the Three-dimensional Pharmacophore of κ‐opioid Receptor Agonists
Bioorg Med Chem
18/ 12, 4446–4452
2010/06


58 Imaide S, Fujii H, Watanabe A, Nemoto T, Nakajima M, Nakao K, Mochizuki H, Nagase H
Investigation of Beckett-Casy model 1:Synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology
Bioorg Med Chem Lett
20/ 3, 1055-1058
2010/02


59 Nagase H, Watanabe A, Nemoto T, Yamaotsu N, Hayashida K, Nakajima M, Hasebe K, Nakao K, Mochizuki H, Hirono S, Fujii H
Drug design and synthesis of a novel opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology
Bioorg Med Chem Lett
20/ 1, 121-124
2010/01


60 Fujii H, Imaide S, Watanabe A, Yoza K, Nakajima M, Nakao K, Mochizuki H, Sato N, Nemoto T, Nagase H
A double decarboxylation reaction of an oxazolidinone and carboxylic acid:Its application to the synthesis of a new opioid lead compound
J Org Chem
75/ 3, 995-998
2010/01


61 Fujii H, Okada K, Ishihara M, Hanamura S, Osa Y, Nemoto T, Nagase H
Hydrogenolysis of the cyclopropyl group into an isopropyl group in the presence of a platinum catalyst and hydrobromic acid
Tetrahedron
65/ 51, 10623-10630
2009/12


62 Fujii H, Okada K, Ishihara M, Hanamura S, Osa Y, Nemoto T, Nagase H
Hydrogenolysis of the cyclopropyl group into an isopropyl group in the presence of a platinum catalyst and hydrobromic acid
Tetrahedron
65/ 51, 10623-10630
2009/12


63 Fujii H, Ogawa R, Jinbo E, Tsumura S, Nemoto T, Nagase H
Novel oxidation reaction of tertiary amines with osmium tetroxide
Synlett
14, 2341-2345
2009/09


64 Fujii H, Ogawa R, Ohata K, Nemoto T, Nakajima M, Hasebe K, Mochizuki H, Nagase H
Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative
Bioorg Med Chem
17/ 16, 5983-5988
2009/08


65 Fujii H, Watanabe Y, Osa Y, Nemoto T, Sato N, Nagase H
Novel rearrangement reaction of a 6,14-endoethanomorphinan derivative to a benzomorphan derivative
Tetrahedron
65/ 25, 4808-4813
2009/06


66 Nagase H, Osa Y, Nemoto T, Fujii H, Imai M, Nakamura T, Kanemasa T, Kato A, Gouda H, Hirono S
Design and synthesis of novel delta opioid receptor agonist and their pharmacologies
Bioorg Med Chem Lett
19/ 10, 2792-2795
2009/05


67 Watanabe A,Fujii H,Nakajima M,Hasebe K,Mochizuki H,Nagase H
Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction
Bioorg Med Chem Lett
19/ 9, 2416-2419
2009/03


68 Nagase H,Watanabe A,Harada M,Nakajima M,Hasebe K,Mochizuki H,Yoza K,Fujii H
Novel synthesis of a 1,3,5-trioxazatriquinane skeleton using a nitrogen clamp
Org Lett
11/ 3, 539-542
2009/02


69 Fujii H,Watanabe A,Nemoto T,Narita M,Miyoshi K,Nakamura A,Suzuki T,Nagase H
Synthesis of novel twin drug consisting of 8-oxaendoethanotetrahydromorphides with a 1,4-dioxane spacer and its pharmacological activities: mu, kappa, and putative epsilon opioid receptor antagonists
Bioorg Med Chem Lett
19/ 2, 438-441
2009/01


70 Nemoto T,Fujii H,Narita M,Miyoshi K,Nakamura A,Suzuki T,Nagase H
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology
Bioorg Med Chem Lett
18/ 24, 6398-6401
2008/12


71 Nagase H,Yamamoto N,Nemoto T,Yoza K,Kamiya K,Hirono S,Momen S,Izumimoto N,Hasebe K,Mochizuki H,Fujii H
Synthesis of a stable iminium salt and propellane derivatives
J Org Chem
73/ 20, 8093-8096
2008/10


72 Kawai K,Hayakawa J,Miyamoto T,Imamura Y,Yamane S,Wakita H,Fujii H,Kawamura K,Matsuura H,Izumimoto N,Kobayashi R,Endo T,Nagase H
Design,Synthesis,and Structure-Activity Relationship of Novel Opioid κ-Agonists
Bioorg Med Chem
16/ 20, 9188-9201
2008/10


73 Nitta A,Fujii H,Sakami S,Nishimura Y,Ohyama T,Satoh M,Nakaki J,Satoh S,Inada C,Kozono H,Kumagai H,Shimamura M,Fukazawa T,Kawai H
(3R)-3-amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl} butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg Med Chem Lett
18/ 20, 5435-5438
2008/10


74 Sakami S,Kawai K,Maeda M,Aoki T,Fujii H,Ohno H,Ito T,Saitoh A,Nakao K,Izumimoto N,Matsuura H,Endo T,Ueno S,Natsume K,Nagase H
Design and synthesis of a metabolically stable and potent antitussive agent, a novel δ opioid receptor antagonist, TRK-851
Bioorg Med Chem
16/ 17, 7956-7967
2008/09


75 Fujii H,Osa Y,Ishihara M,Hanamura S,Nemoto T,Nakajima M,Hasebe K,Mochizuki H,Nagase H
Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction
Bioorg Med Chem Lett
18/ 18, 4978-4981
2008/09


76 Sakami S,Maeda M,Kawai K,Aoki T,Kawamura K,Fujii H,Hasebe K,Nakajima M,Endo T,Ueno S,Ito T,Kamei J,Nagase H
Structure-antitussive activity relationships of naltrindole derivatives. : identification of novel and potent antitussive agents
J Med Chem
51/ 15, 4404-4411
2008/08


77 Fujii H,Imaide S,Watanabe A,Nemoto T,Nagase H
Novel cleavage reaction of the C16-N17 bond in naltrexone derivatives
Tetrahedron Lett
49/ 44, 6293-6296
2008/08


78 Nemoto T,Fujii H,Narita M,Miyoshi K,Nakamura A,Suzuki T,Nagase H
Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies
Bioorg Med Chem
16/ 8, 4304-4312
2008/04


79 藤井秀明
非ペプチド性GLP-1作動薬/経口糖尿病治療薬への可能性
ファルマシア Vol. 44 No. 1
79-80
2008/01


80 Osa, Y.; Ida. Y.; Fujii, H.; Nemoto, T.; Hasebe, K.; Momen, S.; Mochizuki, H; Nagase, H.
Catalytic Aerobic Oxidation of nor-Binaltorphimine (nor-BNI) Analogs without 4,5-Epoxy Bridge Affords a More Selective Ligand for κ Opioid Receptor than the Representative κ Antagonist nor-BNI
Chem. Pharm. Bull. Vol. 55 No. 10
1489-1493
2007/10


81 Nemoto, T.; Fujii, H.; Sato, N.; Nagase, H.
Synthesis of a novel 4,6'-epoxymorphinan derivative and a highly strained novel conjugated ketone
Tetrahedron Lett. Vol.48 No. 41
7413-7417
2007/08


82 Fujii H, Nagase H
Rational Drug Design of Selective ε Opioid Receptor Agonist TAN-821 and Antagonist TAN-1014
Curr. Med. Chem.
13/ 10, 1109–1118
2006/04

10.2174/092986706776360851
83 Fujii, H.; Narita, M.; Mizoguchi, H.; Hirokawa, J.; Kawai, K.; Tanaka, T.; Tseng, L. F.; Nagase, H.
Rational drug design and synthesis of a selective ε-opioid receptor antagonist on the basis of the accessory site concept.
Bioorg. Med. Chem. Lett. Vol. 14 No. 16
4241-4243
2004/08


84 Fujii, H.; Narita, M.; Mizoguchi, H.; Murachi, M.; Tanaka, T.; Kawai, K.; Tseng, L. F.; Nagase, H.
Drug design and synthesis of ε-opioid -(N-methyl-N-phenethyl)-dihydroxy-6,14-endoethenomorphinan-7-epoxy-3,6,receptor agonist:17-(cyclopropylmethyl)-4,5 carboxamide(TAN-821) inducing antinociception mediated by putative ε-opioid receptor.
Bioorg. Med. Chem. Vol. 12 No. 15
4133-4155
2004/08


85 Fujii, H.; Hirano, N.; Uchiro, H.; Kawamura, K.; Nagase, H.
The First Example of the Stereoselective Synthesis of 7β-Carbamoyl-4,5α-epoxymorphinan via a Nobel and Reactive γ-Lactone.
Chem. Pharm. Bull. vol. 52 No. 6
747-750
2004/06




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